![](/images/graphics-bg.png)
Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus
Joint Authors
Desoye, G.
Cvitic, Silvija
Hiden, Ursula
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The placental vasculature rapidly expands during the course of pregnancy in order to sustain the growing needs of the fetus.
Angiogenesis and vascular growth are stimulated and regulated by a variety of growth factors expressed in the placenta or present in the fetal circulation.
Like in tumors, hypoxia is a major regulator of angiogenesis because of its ability to stimulate expression of various proangiogenic factors.
Chronic fetal hypoxia is often found in pregnancies complicated by maternal diabetes as a result of fetal hyperglycaemia and hyperinsulinemia.
Both are associated with altered levels of hormones, growth factors, and proinflammatory cytokines, which may act in a proangiogenic manner and, hence, affect placental angiogenesis and vascular development.
Indeed, the placenta in diabetes is characterized by hypervascularisation, demonstrating high placental plasticity in response to diabetic metabolic derangements.
This review describes the major regulators of placental angiogenesis and how the diabetic environment in utero alters their expression.
In the light of hypervascularized diabetic placenta, the focus was placed on proangiogenic factors.
American Psychological Association (APA)
Cvitic, Silvija& Desoye, G.& Hiden, Ursula. 2014. Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034385
Modern Language Association (MLA)
Cvitic, Silvija…[et al.]. Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1034385
American Medical Association (AMA)
Cvitic, Silvija& Desoye, G.& Hiden, Ursula. Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034385