Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.
Joint Authors
Parimelazhagan, Thangaraj
Plackal George, Blassan
Sulaiman, Cheruthazhakkatt
Piramanayagam, Shanmughavel
Ramaswamy, Sathish Kumar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds.
Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays.
The promising results of this investigation emphasize the importance of using R.
fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases.
American Psychological Association (APA)
Plackal George, Blassan& Parimelazhagan, Thangaraj& Sulaiman, Cheruthazhakkatt& Piramanayagam, Shanmughavel& Ramaswamy, Sathish Kumar. 2014. Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034399
Modern Language Association (MLA)
Plackal George, Blassan…[et al.]. Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1034399
American Medical Association (AMA)
Plackal George, Blassan& Parimelazhagan, Thangaraj& Sulaiman, Cheruthazhakkatt& Piramanayagam, Shanmughavel& Ramaswamy, Sathish Kumar. Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034399