Adsorption of the Inflammatory Mediator High-Mobility Group Box 1 by Polymers with Different Charge and Porosity
Joint Authors
Eichhorn, Tanja
Tripisciano, Carla
Harm, Stephan
Weber, Viktoria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
High-mobility group box 1 protein (HMGB1) is a conserved protein with a variety of biological functions inside as well as outside the cell.
When released by activated immune cells, it acts as a proinflammatory cytokine.
Its delayed release has sparked the interest in HMGB1 as a potential therapeutic target.
Here, we studied the adsorption of HMGB1 to anionic methacrylate-based polymers as well as to neutral polystyrene-divinylbenzene copolymers.
Both groups of adsorbents exhibited efficient binding of recombinant HMGB1 and of HMGB1 derived from lipopolysaccharide-stimulated peripheral blood mononuclear cells.
The adsorption characteristics depended on particle size, porosity, accessibility of the pores, and charge of the polymers.
In addition to these physicochemical parameters of the adsorbents, modifications of the molecule itself (e.g., acetylation, phosphorylation, and oxidation), interaction with other plasma proteins or anticoagulants (e.g., heparin), or association with extracellular microvesicles may influence the binding of HMGB1 to adsorbents and lead to preferential depletion of HMGB1 subsets with different biological activity.
American Psychological Association (APA)
Tripisciano, Carla& Eichhorn, Tanja& Harm, Stephan& Weber, Viktoria. 2014. Adsorption of the Inflammatory Mediator High-Mobility Group Box 1 by Polymers with Different Charge and Porosity. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034405
Modern Language Association (MLA)
Tripisciano, Carla…[et al.]. Adsorption of the Inflammatory Mediator High-Mobility Group Box 1 by Polymers with Different Charge and Porosity. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034405
American Medical Association (AMA)
Tripisciano, Carla& Eichhorn, Tanja& Harm, Stephan& Weber, Viktoria. Adsorption of the Inflammatory Mediator High-Mobility Group Box 1 by Polymers with Different Charge and Porosity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034405