The Role of MicroRNAs in Ovarian Cancer
Joint Authors
Kinose, Yasuto
Nakamura, Koji
Kimura, Tadashi
Sawada, Kenjiro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ovarian cancer is the most lethal of malignant gynecological tumors.
Its lethality may be due to difficulties in detecting it at an early stage and lack of effective treatments for patients with an advanced or recurrent status.
Therefore, there is a strong need for prognostic and predictive markers to diagnose it early and to help optimize and personalize treatment.
MicroRNAs are noncoding RNAs that regulate target genes posttranscriptionally.
They are involved in carcinogenesis, cell cycle, apoptosis, proliferation, invasion, metastasis, and chemoresistance.
The dysregulation of microRNAs is involved in the initiation and progression of human cancers including ovarian cancer, and strong evidence that microRNAs can act as oncogenes or tumor suppressor genes has emerged.
Several microRNA signatures that are unique to ovarian cancer have been proposed, and serum-circulating microRNAs have the potential to be useful diagnostic and prognostic biomarkers.
Various microRNAs such as those in the miR-200 family, the miR-199/214 cluster, or the let-7 paralogs have potential as therapeutic targets for disseminated or chemoresistant ovarian tumors.
Although many obstacles need to be overcome, microRNA therapy could be a powerful tool for ovarian cancer prevention and treatment.
In this review, we discuss the emerging roles of microRNAs in various aspects of ovarian cancer.
American Psychological Association (APA)
Kinose, Yasuto& Sawada, Kenjiro& Nakamura, Koji& Kimura, Tadashi. 2014. The Role of MicroRNAs in Ovarian Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034408
Modern Language Association (MLA)
Kinose, Yasuto…[et al.]. The Role of MicroRNAs in Ovarian Cancer. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034408
American Medical Association (AMA)
Kinose, Yasuto& Sawada, Kenjiro& Nakamura, Koji& Kimura, Tadashi. The Role of MicroRNAs in Ovarian Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034408