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New Insights into Monoclonal B-Cell Lymphocytosis
Joint Authors
Panayiotidis, Panayiotis P.
Moschogiannis, Maria
Tsirkinidis, Pantelis
Levidou, Georgia
Kyriakaki, Stavroula
Pangalis, Gerassimos A.
Vassilakopoulos, Theodoros P.
Yiakoumis, Xanthi
Papadaki, Helen A.
Angelopoulou, Maria K.
Koulieris, Efstathios
Kalpadakis, Christina
Sachanas, Sotirios
Korkolopoulou, Penelope
Kyrtsonis, Marie-Christine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Monoclonal B-cell lymphocytosis (MBL) is a premalignant condition characterized by the presence of less than 5000/μL circulating clonal B cells in otherwise healthy individuals.
Three subcategories have been identified according to the immunophenotypic features: CLL-like, CD5(+) atypical, and CD5(−) MBL.
CLL-like MBL is by far the most frequent and best studied category and further divided in low-count [LC] and high-count [HC] MBL, based on a cutoff value of 500/μL clonal B cells.
LC-MBL typically remains stable and probably does not represent a truly premalignant condition, but rather an age-related immune senescence.
On the other hand, HC-MBL is closely related to CLL-Rai0, bearing similar immunogenetic profile, and is associated with an annual risk of progression to CLL requiring therapy at a rate of 1.1%.
Currently there are no reproducible factors for evaluating the risk of progression to CLL.
CD5(−) MBL is characterized by an immunophenotype consistent with marginal zone origin and displays many similarities with marginal zone lymphomas (MZL), mainly the splenic MZL.
The cutoff value of 5000/μL clonal B cells cannot probably be applied in CD5(−) MBL, requiring a new definition to describe those cases.
American Psychological Association (APA)
Kalpadakis, Christina& Pangalis, Gerassimos A.& Sachanas, Sotirios& Vassilakopoulos, Theodoros P.& Kyriakaki, Stavroula& Korkolopoulou, Penelope…[et al.]. 2014. New Insights into Monoclonal B-Cell Lymphocytosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034411
Modern Language Association (MLA)
Kalpadakis, Christina…[et al.]. New Insights into Monoclonal B-Cell Lymphocytosis. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034411
American Medical Association (AMA)
Kalpadakis, Christina& Pangalis, Gerassimos A.& Sachanas, Sotirios& Vassilakopoulos, Theodoros P.& Kyriakaki, Stavroula& Korkolopoulou, Penelope…[et al.]. New Insights into Monoclonal B-Cell Lymphocytosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034411