Cysteine Cathepsin Activity Regulation by Glycosaminoglycans
Joint Authors
Novinec, Marko
Turk, Boris
Lenarcic, B.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cysteine cathepsins are a group of enzymes normally found in the endolysosomes where they are primarily involved in intracellular protein turnover but also have a critical role in MHC II-mediated antigen processing and presentation.
However, in a number of pathologies cysteine cathepsins were found to be heavily upregulated and secreted into extracellular milieu, where they were found to degrade a number of extracellular proteins.
A major role in modulating cathepsin activities play glycosaminoglycans, which were found not only to facilitate their autocatalytic activation including at neutral pH, but also to critically modulate their activities such as in the case of the collagenolytic activity of cathepsin K.
The interaction between cathepsins and glycosaminoglycans will be discussed in more detail.
American Psychological Association (APA)
Novinec, Marko& Lenarcic, B.& Turk, Boris. 2014. Cysteine Cathepsin Activity Regulation by Glycosaminoglycans. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034429
Modern Language Association (MLA)
Novinec, Marko…[et al.]. Cysteine Cathepsin Activity Regulation by Glycosaminoglycans. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034429
American Medical Association (AMA)
Novinec, Marko& Lenarcic, B.& Turk, Boris. Cysteine Cathepsin Activity Regulation by Glycosaminoglycans. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034429