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Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta
Joint Authors
Tufiño, Cecilia
Ibarra-Barajas, Maximiliano
Bracho-Valdés, Ismael
Bobadilla-Lugo, Rosa Amalia
Villanueva, Cleva
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic conditions increase vascular reactivity to angiotensin II in several studies but there are scarce reports on cardiovascular effects of hypercaloric diet (HD) induced gestational diabetes mellitus (GDM), so the objective of this work was to determine the effects of HD induced GDM on vascular responses.
Angiotensin II as well as phenylephrine induced vascular contraction was tested in isolated aorta rings with and without endothelium from rats fed for 7 weeks (4 before and 3 weeks during pregnancy) with standard (SD) or hypercaloric (HD) diet.
Also, protein expression of AT1R, AT2R, COX-1, COX-2, NOS-1, and NOS-3 and plasma glucose, insulin, and angiotensin II levels were measured.
GDM impaired vasoconstrictor response ( P < 0.05 versus SD) in intact (e+) but not in endothelium-free (e−) vessels.
Losartan reduced GDM but not SD e− vasoconstriction ( P < 0.01 versus SD).
AT1R, AT2R, and COX-1 and COX-2 protein expression were significantly increased in GDM vessels ( P < 0.05 versus SD).
Results suggest an increased participation of endothelium vasodilator mediators, probably prostaglandins, as well as of AT2 vasodilator receptors as a compensatory mechanism for vasoconstrictor changes generated by experimental GDM.
Considering the short term of rat pregnancy findings can reflect early stage GDM adaptations.
American Psychological Association (APA)
Tufiño, Cecilia& Villanueva, Cleva& Ibarra-Barajas, Maximiliano& Bracho-Valdés, Ismael& Bobadilla-Lugo, Rosa Amalia. 2014. Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034434
Modern Language Association (MLA)
Tufiño, Cecilia…[et al.]. Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034434
American Medical Association (AMA)
Tufiño, Cecilia& Villanueva, Cleva& Ibarra-Barajas, Maximiliano& Bracho-Valdés, Ismael& Bobadilla-Lugo, Rosa Amalia. Experimental Gestational Diabetes Mellitus Induces Blunted Vasoconstriction and Functional Changes in the Rat Aorta. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034434