The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment
Joint Authors
Huang, Chun-Yin
Tang, Chih-Hsin
Su, Chen-Ming
Chou, Pei-Yu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Osteoarthritis (OA) is a mechanical abnormality associated with degradation of joints.
It is characterized by chronic, progressive degeneration of articular cartilage, abnormalities of bone, and synovial change.
The most common symptom of OA is local inflammation resulting from exogenous stress or endogenous abnormal cytokines.
Additionally, OA is associated with local and/or systemic activation of coagulation and anticoagulation pathways.
Thrombin plays an important role in the stimulation of fibrin deposition and the proinflammatory processes in OA.
Thrombin mediates hemostatic and inflammatory responses and guides the immune response to tissue damage.
Thrombin activates intracellular signaling pathways by interacting with transmembrane domain G protein coupled receptors (GPCRs), known as protease-activated receptors (PARs).
In pathogenic mechanisms, PARs have been implicated in the development of acute and chronic inflammatory responses in OA.
Therefore, discovery of thrombin signaling pathways would help us to understand the mechanism of OA pathogenesis and lead us to develop therapeutic drugs in the future.
American Psychological Association (APA)
Chou, Pei-Yu& Su, Chen-Ming& Huang, Chun-Yin& Tang, Chih-Hsin. 2014. The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034453
Modern Language Association (MLA)
Chou, Pei-Yu…[et al.]. The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034453
American Medical Association (AMA)
Chou, Pei-Yu& Su, Chen-Ming& Huang, Chun-Yin& Tang, Chih-Hsin. The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034453