Increased Serum Levels of Inflammatory Mediators and Low Frequency of Regulatory T Cells in the Peripheral Blood of Preeclamptic Mexican Women
Joint Authors
Tovar-Rodríguez, José María
Vargas-Avila, Karina
Nieto-Velázquez, Nayeli Goreti
Frías-De-León, María Guadalupe
Sierra-Martinez, Mónica
Acosta-Altamirano, Gustavo
Moreno-Eutimio, Mario Adan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Regulatory T cells ( T regs ; CD4+CD2 5 high Foxp3+) are critical in maintaining immune tolerance during pregnancy and uterine vascularization.
In this study, we show that, in Mexican women with different preeclamptic severity levels, the number of T regs and the subset of CD4+CD2 5 high Foxp3+ are decreased compared with those of normotensive pregnant women (NP).
Moreover, a systemic inflammatory state is a pivotal feature in the pathogenesis of this disorder and could be related to hypertension and endothelial dysfunction.
Likewise, we observed elevated levels of IL-6, TNF-α, and IL-8 in the serum of severe preeclamptic patients (SPE); no differences were found in the IL-1β and IL-10 levels compared with those of NP patients.
An analysis of chemokines in the preeclamptic serum samples showed high levels of CXCL10, CCL2, and CXCL9.
Our findings suggest that the preeclamptic state is linked with systemic inflammation and reduced numbers of T regs .
American Psychological Association (APA)
Moreno-Eutimio, Mario Adan& Tovar-Rodríguez, José María& Vargas-Avila, Karina& Nieto-Velázquez, Nayeli Goreti& Frías-De-León, María Guadalupe& Sierra-Martinez, Mónica…[et al.]. 2014. Increased Serum Levels of Inflammatory Mediators and Low Frequency of Regulatory T Cells in the Peripheral Blood of Preeclamptic Mexican Women. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034456
Modern Language Association (MLA)
Moreno-Eutimio, Mario Adan…[et al.]. Increased Serum Levels of Inflammatory Mediators and Low Frequency of Regulatory T Cells in the Peripheral Blood of Preeclamptic Mexican Women. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034456
American Medical Association (AMA)
Moreno-Eutimio, Mario Adan& Tovar-Rodríguez, José María& Vargas-Avila, Karina& Nieto-Velázquez, Nayeli Goreti& Frías-De-León, María Guadalupe& Sierra-Martinez, Mónica…[et al.]. Increased Serum Levels of Inflammatory Mediators and Low Frequency of Regulatory T Cells in the Peripheral Blood of Preeclamptic Mexican Women. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034456