Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials
Joint Authors
Xanthos, Theodoros
Cossu, Andrea Pasquale
Mura, Paolo
De Giudici, Lorenzo Matteo
Puddu, Daniela
Pasin, Laura
Evangelista, Maurizio
Musu, Mario
Finco, G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The latest European guidelines for the management of hemorrhagic shock suggest the use of vasopressors (norepinephrine) in order to restore an adequate mean arterial pressure when fluid resuscitation therapy fails to restore blood pressure.
The administration of arginine vasopressin (AVP), or its analogue terlipressin, has been proposed as an alternative treatment in the early stages of hypovolemic shock.
Design.
A meta-analysis of randomized controlled animal trials.
Participants.
A total of 433 animals from 15 studies were included.
Interventions.
The ability of AVP and terlipressin to reduce mortality when compared with fluid resuscitation therapy, other vasopressors (norepinephrine or epinephrine), or placebo was investigated.
Measurements and Main Results.
Pooled estimates showed that AVP and terlipressin consistently and significantly improve survival in hemorrhagic shock (mortality: 26/174 (15%) in the AVP group versus 164/259 (63%) in the control arms; OR = 0.09 ; 95% CI 0.05 to 0.15; P for effect < 0.001; P for heterogeneity = 0.30; I 2 = 14 % ).
Conclusions.
Results suggest that AVP and terlipressin improve survival in the early phases of animal models of hemorrhagic shock.
Vasopressin seems to be more effective than all other treatments, including other vasopressor drugs.
These results need to be confirmed by human clinical trials.
American Psychological Association (APA)
Cossu, Andrea Pasquale& Mura, Paolo& De Giudici, Lorenzo Matteo& Puddu, Daniela& Pasin, Laura& Evangelista, Maurizio…[et al.]. 2014. Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034459
Modern Language Association (MLA)
Cossu, Andrea Pasquale…[et al.]. Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034459
American Medical Association (AMA)
Cossu, Andrea Pasquale& Mura, Paolo& De Giudici, Lorenzo Matteo& Puddu, Daniela& Pasin, Laura& Evangelista, Maurizio…[et al.]. Vasopressin in Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Randomized Animal Trials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034459