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The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model
Joint Authors
Welting, Tim J. M.
Odekerken, Jim C. E.
Walenkamp, Geert H. I. M.
Brans, Boudewijn T.
Arts, Jacobus J. C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Osteomyelitis is a severe orthopaedic complication which is difficult to diagnose and treat.
Previous experimental studies mainly focussed on evaluating osteomyelitis in the presence of an implant or used a sclerosing agent to promote infection onset.
In contrast, we focused on the longitudinal assessment of a nonimplant related osteomyelitis.
Methods.
An intramedullary tibial infection with S.
aureus was established in NZW rabbits.
Clinical and haematological infection status was evaluated weekly, combined with X-ray radiographs, biweekly injections of calcium binding fluorophores, and postmortem micro-CT.
The development of the infection was assessed by micro-PET at consecutive time points using 18F-FDG as an infection tracer.
Results.
The intramedullary contamination of the rabbit tibia resulted in an osteomyelitis.
Haematological parameters confirmed infection in mainly the first postoperative weeks (CRP at the first 5 postoperative weeks, leucocyte differentiation at the second and sixth postoperative weeks, and ESR on the second postoperative week only), while micro-PET was able to detect the infection from the first post-operative week onward until the end of the study.
Conclusions.
This study shows that osteomyelitis in the rabbit can be induced without use of an implant or sclerosing agent.
The sequential follow-up indicates that the diagnostic value of each infection parameter is time point dependant.
Furthermore, from all parameters used, the diagnostic value of 18F-FDG micro-PET is the most versatile to assess the presence of an orthopaedic infection in this model.
American Psychological Association (APA)
Odekerken, Jim C. E.& Walenkamp, Geert H. I. M.& Brans, Boudewijn T.& Welting, Tim J. M.& Arts, Jacobus J. C.. 2014. The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034462
Modern Language Association (MLA)
Odekerken, Jim C. E.…[et al.]. The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034462
American Medical Association (AMA)
Odekerken, Jim C. E.& Walenkamp, Geert H. I. M.& Brans, Boudewijn T.& Welting, Tim J. M.& Arts, Jacobus J. C.. The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034462