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Myristic Acid Produces Anxiolytic-Like Effects in Wistar Rats in the Elevated Plus Maze
Joint Authors
Contreras, C. M.
Rodríguez-Landa, Juan Francisco
García-Ríos, Rosa Isela
Bernal-Morales, Blandina
Cueto-Escobedo, Jonathan
Guillen-Ruiz, Gabriel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A mixture of eight fatty acids (linoleic, palmitic, stearic, myristic, elaidic, lauric, oleic, and palmitoleic acids) at similar concentrations identified in human amniotic fluid produces anxiolytic-like effects comparable to diazepam in Wistar rats.
However, individual effects of each fatty acid remain unexplored.
In Wistar rats, we evaluated the separate action of each fatty acid at the corresponding concentrations previously found in human amniotic fluid on anxiety-like behaviour.
Individual effects were compared with vehicle, an artificial mixture of the same eight fatty acids, and a reference anxiolytic drug (diazepam, 2 mg/kg).
Myristic acid, the fatty acid mixture, and diazepam increased the time spent in the open arms of the elevated plus maze and reduced the anxiety index compared with vehicle, without altering general locomotor activity.
The other fatty acids had no effect on anxiety-like behaviour, but oleic acid reduced locomotor activity.
Additionally, myristic acid produced anxiolytic-like effects only when the concentration corresponded to the one identified in human amniotic fluid (30 ?g/mL) but did not alter locomotor activity.
We conclude that of the eight fatty acids contained in the fatty acid mixture, only myristic acid produces anxiolytic-like effects when administered individually at a similar concentration detected in human amniotic fluid.
American Psychological Association (APA)
Contreras, C. M.& Rodríguez-Landa, Juan Francisco& García-Ríos, Rosa Isela& Cueto-Escobedo, Jonathan& Guillen-Ruiz, Gabriel& Bernal-Morales, Blandina. 2014. Myristic Acid Produces Anxiolytic-Like Effects in Wistar Rats in the Elevated Plus Maze. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034477
Modern Language Association (MLA)
Contreras, C. M.…[et al.]. Myristic Acid Produces Anxiolytic-Like Effects in Wistar Rats in the Elevated Plus Maze. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034477
American Medical Association (AMA)
Contreras, C. M.& Rodríguez-Landa, Juan Francisco& García-Ríos, Rosa Isela& Cueto-Escobedo, Jonathan& Guillen-Ruiz, Gabriel& Bernal-Morales, Blandina. Myristic Acid Produces Anxiolytic-Like Effects in Wistar Rats in the Elevated Plus Maze. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034477