Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra
Joint Authors
Corradini, Beatriz Raposo
Iamashita, Priscila
Tampellini, Edilaine
Farfel, José Marcelo
Grinberg, Lea Tenenholz
Moreira-Filho, Carlos Alberto
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Parkinson’s disease (PD)—classically characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta—has a caudal-rostral progression, beginning in the dorsal motor vagal nucleus and, in a less extent, in the olfactory system, progressing to the midbrain and eventually to the basal forebrain and the neocortex.
About 90% of the cases are idiopathic.
To study the molecular mechanisms involved in idiopathic PD we conducted a comparative study of transcriptional interaction networks in the dorsal motor vagal nucleus (VA), locus coeruleus (LC), and substantia nigra (SN) of idiopathic PD in Braak stages 4-5 (PD) and disease-free controls (CT) using postmortem samples.
Gene coexpression networks (GCNs) for each brain region (patients and controls) were obtained to identify highly connected relevant genes (hubs) and densely interconnected gene sets (modules).
GCN analyses showed differences in topology and module composition between CT and PD networks for each anatomic region.
In CT networks, VA, LC, and SN hub modules are predominantly associated with neuroprotection and homeostasis in the ageing brain, whereas in the patient’s group, for the three brain regions, hub modules are mostly related to stress response and neuron survival/degeneration mechanisms.
American Psychological Association (APA)
Corradini, Beatriz Raposo& Iamashita, Priscila& Tampellini, Edilaine& Farfel, José Marcelo& Grinberg, Lea Tenenholz& Moreira-Filho, Carlos Alberto. 2014. Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1034495
Modern Language Association (MLA)
Corradini, Beatriz Raposo…[et al.]. Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1034495
American Medical Association (AMA)
Corradini, Beatriz Raposo& Iamashita, Priscila& Tampellini, Edilaine& Farfel, José Marcelo& Grinberg, Lea Tenenholz& Moreira-Filho, Carlos Alberto. Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson’s Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1034495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034495