![](/images/graphics-bg.png)
The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis
Joint Authors
D’Ascenzo, Fabrizio
Barbero, Umberto
Bisi, Marta
Moretti, Claudio
Omedè, Pierluigi
Cerrato, Enrico
Quadri, Giorgio
Conrotto, Federico
Zoccai, Giuseppe Biondi
DiNicolantonio, James J.
Gasparini, Mauro
Bangalore, Sripal
Gaita, Fiorenzo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Negative results of recent randomized clinical trials testing the hypothesis of target therapy for patients with high on-treatment platelet reactivity (HOPR) have questioned its independent impact on clinical outcomes.
26 studies with 28.178 patients were included, with a median age of 66.8 (64–68) and 22.7% (22.4–27.8), of female gender.
After a median follow-up of 1 year (0.1–1), cardiac adverse events occurred in 8.3% (3–11; all results are reported as median and interquartile range) of patients.
Pooling all studies together, on-treatment platelet reactivity significantly increased the risk of adverse events (OR 1.33 [1.09, 1.64], I 2 = 0 % ).
However, a sensitivity analysis showed that HOPR did not increase the risk of adverse events for patients with ACS, AMI, or stable angina as well as patients resistant to aspirin, ADP antagonists, or both.
For all studies, publication bias was formally evident; after adjusting for this, HOPR did not significantly increase adverse cardiac events (OR 1.1 : 0.89–1.22, I 2 0%).
Conclusions.
After adjusting for clinical confounders (like risk factors and clinical presentation) and for relevant publication bias, HOPR was not an independent prognostic indicator in unselected patients with both stable and unstable coronary disease for an adverse cardiac event.
The clinical importance of HOPR for high-risk populations remains to be assessed.
American Psychological Association (APA)
D’Ascenzo, Fabrizio& Barbero, Umberto& Bisi, Marta& Moretti, Claudio& Omedè, Pierluigi& Cerrato, Enrico…[et al.]. 2014. The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034505
Modern Language Association (MLA)
D’Ascenzo, Fabrizio…[et al.]. The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1034505
American Medical Association (AMA)
D’Ascenzo, Fabrizio& Barbero, Umberto& Bisi, Marta& Moretti, Claudio& Omedè, Pierluigi& Cerrato, Enrico…[et al.]. The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034505