Binding Sites of miR-1273 Family on the mRNA of Target Genes
Joint Authors
Pyrkova, Anna
Niyazova, Raigul
Ivashchenko, Anatoly
Berillo, Olga
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study examined binding sites of 2,578 miRNAs in the mRNAs of 12,175 human genes using the MirTarget program.
It found that the miRNAs of miR-1273 family have between 33 and 1,074 mRNA target genes, with a free hybridization energy of 90% or more of its maximum value.
The miR-1273 family consists of miR-1273a, miR-1273c, miR-1273d, miR-1273e, miR-1273f, miR-1273g-3p, miR-1273g-5p, miR-1273h-3p, and miR-1273h-5p.
Unique miRNAs (miR-1273e, miR-1273f, and miR-1273g-3p) have more than 400 target genes.
We established 99 mRNA nucleotide sequences that contain arranged binding sites for the miR-1273 family.
High conservation of each miRNA binding site in the mRNA of the target genes was found.
The arranged binding sites of the miR-1273 family are located in the 5′UTR, CDS, or 3′UTR of many mRNAs.
Five repeating sites containing some of the miR-1273 family’s binding sites were found in the 3′UTR of several target genes.
The oligonucleotide sequences of miR-1273 binding sites located in CDSs code for homologous amino acid sequences in the proteins of target genes.
The biological role of unique miRNAs was also discussed.
American Psychological Association (APA)
Ivashchenko, Anatoly& Berillo, Olga& Pyrkova, Anna& Niyazova, Raigul. 2014. Binding Sites of miR-1273 Family on the mRNA of Target Genes. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034513
Modern Language Association (MLA)
Ivashchenko, Anatoly…[et al.]. Binding Sites of miR-1273 Family on the mRNA of Target Genes. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034513
American Medical Association (AMA)
Ivashchenko, Anatoly& Berillo, Olga& Pyrkova, Anna& Niyazova, Raigul. Binding Sites of miR-1273 Family on the mRNA of Target Genes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034513