Enhanced Prevalence of Plasmatic Soluble MHC Class I Chain-Related Molecule in Vascular Pregnancy Diseases
Joint Authors
Haumonte, Jean Baptiste
Caillat-Zucman, Sophie
Bretelle, Florence
Lambert, Marion
Lyonnet, Luc
Levy-Mozziconacci, Annie
Aubert, Agostini
Boubli, Leon
Camoin-Jau, Laurence
Dignat George, Françoise
Paul, Pascale
Farnarier, Catherine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The major histocompatibility complex class I related chain (MIC) is a stress-inducible protein modulating the function of immune natural killer (NK) cells, a major leukocyte subset involved in proper trophoblast invasion and spiral artery remodeling.
Aim of the study was to evaluate whether upregulation of soluble MIC (sMIC) may reflect immune disorders associated to vascular pregnancy diseases (VPD).
sMIC was more frequently detected in the plasma of women with a diagnostic of VPD (32%) than in normal term-matched pregnancies (1.6%, P < 0.0001 ), with highest prevalence in intrauterine fetal death (IUDF, 44%) and vascular intrauterine growth restriction (IUGR, 39%).
sMIC levels were higher in preeclampsia (PE) than in IUFD ( P < 0.01 ) and vascular IUGR ( P < 0.05 ).
sMIC detection was associated with bilateral early diastolic uterine notches ( P = 0.037 ), thrombocytopenia ( P = 0.03 ), and high proteinuria ( P = 0.03 ) in PE and with the vascular etiology of IUGR ( P = 0.0038 ).
Incubation of sMIC-positive PE plasma resulted in downregulation of NKG2D expression and NK cell-mediated IFN-γ production in vitro.
Our work thus suggests that detection of sMIC molecule in maternal plasma may constitute a hallmark of altered maternal immune functions that contributes to vascular disorders that complicate pregnancy, notably by impairing NK-cell mediated production of IFN-γ, an essential cytokine favoring vascular modeling.
American Psychological Association (APA)
Haumonte, Jean Baptiste& Caillat-Zucman, Sophie& Bretelle, Florence& Lambert, Marion& Lyonnet, Luc& Levy-Mozziconacci, Annie…[et al.]. 2014. Enhanced Prevalence of Plasmatic Soluble MHC Class I Chain-Related Molecule in Vascular Pregnancy Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034526
Modern Language Association (MLA)
Haumonte, Jean Baptiste…[et al.]. Enhanced Prevalence of Plasmatic Soluble MHC Class I Chain-Related Molecule in Vascular Pregnancy Diseases. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034526
American Medical Association (AMA)
Haumonte, Jean Baptiste& Caillat-Zucman, Sophie& Bretelle, Florence& Lambert, Marion& Lyonnet, Luc& Levy-Mozziconacci, Annie…[et al.]. Enhanced Prevalence of Plasmatic Soluble MHC Class I Chain-Related Molecule in Vascular Pregnancy Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034526