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IGF-1 and ADMA Levels Are Inversely Correlated in Nondiabetic Ankylosing Spondylitis Patients Undergoing Anti-TNF-Alpha Therapy
Joint Authors
Miranda-Filloy, José A.
Ubilla, Begoña
González-Juanatey, Carlos
Gonzalez-Gay, Miguel A.
Rueda-Gotor, Javier
Villar-Bonet, Aurelia
Gómez-Acebo, Inés
Llorca, Javier
Blanco, Ricardo
Pina, Trinitario
López-Mejías, Raquel
Genre, Fernanda
Carnero-López, Beatriz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Like rheumatoid arthritis, ankylosing spondylitis (AS) is also an inflammatory disease associated with accelerated atherosclerosis and the presence of metabolic syndrome (MeS) features.
AS patients often display osteoporosis as well as new bone formation.
Insulin-like growth factor 1 (IGF-1) is a protein involved in both inflammation and bone metabolism.
In the present study we assessed whether disease activity, systemic inflammation, MeS features, adipokines, and biomarkers of endothelial activation were associated with IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) levels in a series of 30 nondiabetic AS patients without CV disease undergoing TNF-α antagonist-infliximab therapy.
All determinations were made in the fasting state, immediately before an infliximab infusion.
Although no association of IGF-1 and IGFBP-3 levels with angiopoietin-2 or osteopontin was found, an inverse correlation between IGF-1 levels and asymmetric dimethylarginine (ADMA), an endogenous endothelial nitric oxide synthase inhibitor that impairs nitric oxide production and secretion promoting endothelial dysfunction, was found (r=-0.397; P=0.04).
However, no significant association was found between IGF-1 and IGFBP-3 levels and disease activity, systemic inflammation, metabolic syndrome features, or adipokines.
In conclusion, in nondiabetic patients with AS undergoing periodic anti-TNF-α therapy, IGF-1 and ADMA are inversely correlated.
American Psychological Association (APA)
Genre, Fernanda& López-Mejías, Raquel& Rueda-Gotor, Javier& Miranda-Filloy, José A.& Ubilla, Begoña& Villar-Bonet, Aurelia…[et al.]. 2014. IGF-1 and ADMA Levels Are Inversely Correlated in Nondiabetic Ankylosing Spondylitis Patients Undergoing Anti-TNF-Alpha Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034528
Modern Language Association (MLA)
Genre, Fernanda…[et al.]. IGF-1 and ADMA Levels Are Inversely Correlated in Nondiabetic Ankylosing Spondylitis Patients Undergoing Anti-TNF-Alpha Therapy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1034528
American Medical Association (AMA)
Genre, Fernanda& López-Mejías, Raquel& Rueda-Gotor, Javier& Miranda-Filloy, José A.& Ubilla, Begoña& Villar-Bonet, Aurelia…[et al.]. IGF-1 and ADMA Levels Are Inversely Correlated in Nondiabetic Ankylosing Spondylitis Patients Undergoing Anti-TNF-Alpha Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034528