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The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions
Joint Authors
Rice, Gregory E.
Mitchell, Murray D.
Yee, Sarah W.
Salomon, Carlos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A tenet of contemporary obstetrics is that events that compromise placentation increase the risk of complications of pregnancy and contribute to poor pregnancy outcome.
In particular, conditions that affect the invasion of placental cells and remodeling of uterine spiral arteries compromise placental function and the subsequent development of the fetus.
Extravillous trophoblast cells (EVTs) proliferate and migrate from the cytotrophoblast in the anchoring villi of the placenta and invade the maternal decidua and myometrium.
These cells are localised with uterine uterine spiral arteries and are thought to induce vascular remodeling.
A newly identified pathway by which EVTs may regulate vascular remodeling within the uterus is via the release of exosomes.
Trophoblast cells release exosomes that mediate aspects of cell-to-cell communication.
The aim of this brief commentary is to review the putative role of exosomes released from extravillous trophoblast cells in uterine spiral artery remodeling and, in particular, their role in the aetiology of preeclampsia.
Placental exosomes may engage in local cell-to-cell communication between the cell constituents of the placenta and contiguous maternal tissues and/or distal interactions, involving the release of placental exosomes into biological fluids and their transport to a remote site of action.
American Psychological Association (APA)
Salomon, Carlos& Yee, Sarah W.& Mitchell, Murray D.& Rice, Gregory E.. 2014. The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034539
Modern Language Association (MLA)
Salomon, Carlos…[et al.]. The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034539
American Medical Association (AMA)
Salomon, Carlos& Yee, Sarah W.& Mitchell, Murray D.& Rice, Gregory E.. The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034539