A Least Square Method Based Model for Identifying Protein Complexes in Protein-Protein Interaction Network
Joint Authors
Guo, Yingjie
Liu, Yang
Dai, Qiguo
Liu, Xiaoyan
Guo, Maozu
Teng, Zhixia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Protein complex formed by a group of physical interacting proteins plays a crucial role in cell activities.
Great effort has been made to computationally identify protein complexes from protein-protein interaction (PPI) network.
However, the accuracy of the prediction is still far from being satisfactory, because the topological structures of protein complexes in the PPI network are too complicated.
This paper proposes a novel optimization framework to detect complexes from PPI network, named PLSMC.
The method is on the basis of the fact that if two proteins are in a common complex, they are likely to be interacting.
PLSMC employs this relation to determine complexes by a penalized least squares method.
PLSMC is applied to several public yeast PPI networks, and compared with several state-of-the-art methods.
The results indicate that PLSMC outperforms other methods.
In particular, complexes predicted by PLSMC can match known complexes with a higher accuracy than other methods.
Furthermore, the predicted complexes have high functional homogeneity.
American Psychological Association (APA)
Dai, Qiguo& Guo, Maozu& Guo, Yingjie& Liu, Xiaoyan& Liu, Yang& Teng, Zhixia. 2014. A Least Square Method Based Model for Identifying Protein Complexes in Protein-Protein Interaction Network. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034546
Modern Language Association (MLA)
Dai, Qiguo…[et al.]. A Least Square Method Based Model for Identifying Protein Complexes in Protein-Protein Interaction Network. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034546
American Medical Association (AMA)
Dai, Qiguo& Guo, Maozu& Guo, Yingjie& Liu, Xiaoyan& Liu, Yang& Teng, Zhixia. A Least Square Method Based Model for Identifying Protein Complexes in Protein-Protein Interaction Network. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034546