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Hyaluronan-Phosphatidylethanolamine Polymers Form Pericellular Coats on Keratinocytes and Promote Basal Keratinocyte Proliferation
Joint Authors
Turley, Eva A.
Symonette, Caitlin J.
Kaur Mann, Aman
Tan, Xiao Cherie
Ma, Jenny
Perera, Francisco
Tolg, Cornelia
Yazdani, Arjang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aged keratinocytes have diminished proliferative capacity and hyaluronan (HA) cell coats, which are losses that contribute to atrophic skin characterized by reduced barrier and repair functions.
We formulated HA-phospholipid (phosphatidylethanolamine, HA-PE) polymers that form pericellular coats around cultured dermal fibroblasts independently of CD44 or RHAMM display.
We investigated the ability of these HA-PE polymers to penetrate into aged mouse skin and restore epidermal function in vivo.
Topically applied Alexa647-HA-PE penetrated into the epidermis and dermis, where it associated with both keratinocytes and fibroblasts.
In contrast, Alexa647-HA was largely retained in the outer cornified layer of the epidermis and quantification of fluorescence confirmed that significantly more Alexa647-HA-PE penetrated into and was retained within the epidermis than Alexa647-HA.
Multiple topical applications of HA-PE to shaved mouse skin significantly stimulated basal keratinocyte proliferation and epidermal thickness compared to HA or vehicle cream alone.
HA-PE had no detectable effect on keratinocyte differentiation and did not promote local or systemic inflammation.
These effects of HA-PE polymers are similar to those reported for endogenous epidermal HA in youthful skin and show that topical application of HA-PE polymers can restore some of the impaired functions of aged epidermis.
American Psychological Association (APA)
Symonette, Caitlin J.& Kaur Mann, Aman& Tan, Xiao Cherie& Tolg, Cornelia& Ma, Jenny& Perera, Francisco…[et al.]. 2014. Hyaluronan-Phosphatidylethanolamine Polymers Form Pericellular Coats on Keratinocytes and Promote Basal Keratinocyte Proliferation. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1034549
Modern Language Association (MLA)
Symonette, Caitlin J.…[et al.]. Hyaluronan-Phosphatidylethanolamine Polymers Form Pericellular Coats on Keratinocytes and Promote Basal Keratinocyte Proliferation. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1034549
American Medical Association (AMA)
Symonette, Caitlin J.& Kaur Mann, Aman& Tan, Xiao Cherie& Tolg, Cornelia& Ma, Jenny& Perera, Francisco…[et al.]. Hyaluronan-Phosphatidylethanolamine Polymers Form Pericellular Coats on Keratinocytes and Promote Basal Keratinocyte Proliferation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1034549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034549