Dendritic Cell Profile Induced by Schistosoma mansoni Antigen in Cutaneous Leishmaniasis Patients
Joint Authors
Lopes, Diego Mota
Cardoso, Thiago Marconi de Souza
Bafica, Aline Michele Barbosa
Fernandes, Jamille Souza
Cardoso, Luciana Santos
Carvalho, Edgar M.
Araujo, Maria Ilma
Oliveira, Sérgio Costa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The inflammatory response in cutaneous leishmaniasis (CL), although responsible for controlling the infection, is associated with the pathogenesis of disease.
Conversely, the immune response induced by S.
mansoni antigens is able to prevent immune-mediated diseases.
The aim of this study was to evaluate the potential of the S.
mansoni Sm29 antigen to change the profile of monocyte-derived dendritic cells (MoDCs) from subjects with cutaneous leishmaniasis (CL) in vitro.
Monocytes derived from the peripheral blood mononuclear cells of twelve patients were cultured with GM-CSF and IL-4 for differentiation into dendritic cells and then stimulated with soluble Leishmania antigen (SLA) in the presence or absence of Sm29 antigen.
The expression of surface molecules associated with maturation and activation (HLA-DR, CD40, CD83, CD80, and CD86), inflammation (IL-12, TNF), and downregulation (IL-10, IL-10R) was evaluated using flow cytometry.
We observed that the frequencies of HLA-DR, CD83, CD80, and CD86 as well as of IL-10 and IL-10R on MoDCs were higher in cultures stimulated with Sm29, compared to the unstimulated cell cultures.
Our results indicate that the Sm29 antigen is able to activate regulatory MoDCs in patients with cutaneous leishmaniasis.
It might be useful to control the inflammatory process associated with this disease.
American Psychological Association (APA)
Lopes, Diego Mota& Fernandes, Jamille Souza& Cardoso, Thiago Marconi de Souza& Bafica, Aline Michele Barbosa& Oliveira, Sérgio Costa& Carvalho, Edgar M.…[et al.]. 2014. Dendritic Cell Profile Induced by Schistosoma mansoni Antigen in Cutaneous Leishmaniasis Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034554
Modern Language Association (MLA)
Lopes, Diego Mota…[et al.]. Dendritic Cell Profile Induced by Schistosoma mansoni Antigen in Cutaneous Leishmaniasis Patients. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034554
American Medical Association (AMA)
Lopes, Diego Mota& Fernandes, Jamille Souza& Cardoso, Thiago Marconi de Souza& Bafica, Aline Michele Barbosa& Oliveira, Sérgio Costa& Carvalho, Edgar M.…[et al.]. Dendritic Cell Profile Induced by Schistosoma mansoni Antigen in Cutaneous Leishmaniasis Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034554