![](/images/graphics-bg.png)
Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure
Joint Authors
Wu, Chih-Chiang
Wang, Chih-Lu
Ou, Chia-Yu
Liu, Chieh-An
Chuang, Chia-Ju
Chuang, Hau
Liang, Hsiu-Mei
Yang, Kuender D.
Kuo, Ho-Chang
Chang, Jen-Chieh
Hsu, Te-Yao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development.
This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development.
In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 genotyping were included in the study, and the interactive influences of gender-GSTM1 genotyping-prenatal TSE on childhood asthma development were analyzed.
Among these 591 children, 138 (23.4%) had physician-diagnosed asthma at 6 years of age, and 347 (58.7%) were null-GSTM1.
Prenatal TSE significantly increased the prevalence of childhood asthma in null-GSTM1 children relative to those with positive GSTM1.
Further analysis showed that prenatal TSE significantly increased the risk of childhood asthma in girls with null-GSTM1.
Furthermore, among the children without prenatal TSE, girls with null-GSTM1 had a significantly lower risk of developing childhood asthma and a lower total IgE level at 6 years of age than those with positive GSTM1.
This study demonstrates that the GSTM1 null genotype presents a protective effect against asthma development in girls, but the risk of asthma development increases significantly under prenatal TSE.
American Psychological Association (APA)
Wu, Chih-Chiang& Ou, Chia-Yu& Chang, Jen-Chieh& Hsu, Te-Yao& Kuo, Ho-Chang& Liu, Chieh-An…[et al.]. 2014. Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034561
Modern Language Association (MLA)
Wu, Chih-Chiang…[et al.]. Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034561
American Medical Association (AMA)
Wu, Chih-Chiang& Ou, Chia-Yu& Chang, Jen-Chieh& Hsu, Te-Yao& Kuo, Ho-Chang& Liu, Chieh-An…[et al.]. Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034561