Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS
Joint Authors
Briassoulis, George
Briassouli, Efrossini
Vardas, K.
Goukos, D.
Psarra, K.
Botoula, E.
Tsagarakis, S.
Magira, E.
Routsi, C.
Nanas, S.
Apostolou, Kleovoulos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H).
Methods.
Patients with early (first 48 hrs) SS ( n = 29 ) or SIRS ( n = 29 ) admitted to a university ICU and 16 H were enrolled in the study.
Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers.
ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins.
Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry.
Results.
Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H ( P < 0.003 ).
ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P < 0.005 ).
SS monocytes expressed lower iHSP72 MFI levels compared to H ( P = 0.03 ).
Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate ( P < 0.05 ).
In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10.
Conclusion.
Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis.
In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
American Psychological Association (APA)
Vardas, K.& Apostolou, Kleovoulos& Briassouli, Efrossini& Goukos, D.& Psarra, K.& Botoula, E.…[et al.]. 2014. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034567
Modern Language Association (MLA)
Vardas, K.…[et al.]. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034567
American Medical Association (AMA)
Vardas, K.& Apostolou, Kleovoulos& Briassouli, Efrossini& Goukos, D.& Psarra, K.& Botoula, E.…[et al.]. Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034567