Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies
Joint Authors
Phuah, Neoh Hun
Nagoor, Noor Hasima
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are short noncoding RNA which regulate gene expression by messenger RNA (mRNA) degradation or translation repression.
The plethora of published reports in recent years demonstrated that they play fundamental roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation by acting as tumour suppressor or oncogene, and aberrations in their expressions have been linked to onset and progression of various cancers.
Furthermore, each miRNA is capable of regulating the expression of many genes, allowing them to simultaneously regulate multiple cellular signalling pathways.
Hence, miRNAs have the potential to be used as biomarkers for cancer diagnosis and prognosis as well as therapeutic targets.
Recent studies have shown that natural agents such as curcumin, resveratrol, genistein, epigallocatechin-3-gallate, indole-3-carbinol, and 3,3′-diindolylmethane exert their antiproliferative and/or proapoptotic effects through the regulation of one or more miRNAs.
Therefore, this review will look at the regulation of miRNAs by natural agents as a means to potentially enhance the efficacy of conventional chemotherapy through combinatorial therapies.
It is hoped that this would provide new strategies in cancer therapies to improve overall response and survival outcome in cancer patients.
American Psychological Association (APA)
Phuah, Neoh Hun& Nagoor, Noor Hasima. 2014. Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1034569
Modern Language Association (MLA)
Phuah, Neoh Hun& Nagoor, Noor Hasima. Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1034569
American Medical Association (AMA)
Phuah, Neoh Hun& Nagoor, Noor Hasima. Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1034569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034569