Gonadal Steroids Negatively Modulate Oxidative Stress in CBACa Female Mice Infected with P. berghei ANKA
Joint Authors
Morales-Montor, Jorge
Mosqueda-Romo, Néstor Aarón
Rodríguez-Morales, Ana Laura
Buendía-González, Fidel Orlando
Aguilar-Sánchez, Margarita
Legorreta-Herrera, Martha
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We decreased the level of gonadal steroids in female and male mice by gonadectomy.
We infected these mice with P.
berghei ANKA and observed the subsequent impact on the oxidative stress response.
Intact females developed lower levels of parasitaemia and lost weight faster than intact males.
Gonadectomised female mice displayed increased levels of parasitaemia, increased body mass, and increased anaemia compared with their male counterparts.
In addition, gonadectomised females exhibited lower specific catalase, superoxide dismutase, and glutathione peroxidase activities in their blood and spleen tissues compared with gonadectomised males.
To further study the oxidative stress response in P.
berghei ANKA-infected gonadectomised mice, nitric oxide levels were assessed in the blood and spleen, and MDA levels were assessed in the spleen.
Intact, sham-operated, and gonadectomised female mice exhibited higher levels of nitric oxide in the blood and spleen compared with male mice.
MDA levels were higher in all of the female groups.
Finally, gonadectomy significantly increased the oxidative stress levels in females but not in males.
These data suggest that differential oxidative stress is influenced by oestrogens that may contribute to sexual dimorphism in malaria.
American Psychological Association (APA)
Mosqueda-Romo, Néstor Aarón& Rodríguez-Morales, Ana Laura& Buendía-González, Fidel Orlando& Aguilar-Sánchez, Margarita& Morales-Montor, Jorge& Legorreta-Herrera, Martha. 2014. Gonadal Steroids Negatively Modulate Oxidative Stress in CBACa Female Mice Infected with P. berghei ANKA. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034570
Modern Language Association (MLA)
Mosqueda-Romo, Néstor Aarón…[et al.]. Gonadal Steroids Negatively Modulate Oxidative Stress in CBACa Female Mice Infected with P. berghei ANKA. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034570
American Medical Association (AMA)
Mosqueda-Romo, Néstor Aarón& Rodríguez-Morales, Ana Laura& Buendía-González, Fidel Orlando& Aguilar-Sánchez, Margarita& Morales-Montor, Jorge& Legorreta-Herrera, Martha. Gonadal Steroids Negatively Modulate Oxidative Stress in CBACa Female Mice Infected with P. berghei ANKA. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034570