EXIA2: Web Server of Accurate and Rapid Protein Catalytic Residue Prediction
Joint Authors
Chien, Yu-Tung
Huang, Shao-Wei
Yu, Chin-Sheng
Lu, Chih-Hao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We propose a method (EXIA2) of catalytic residue prediction based on protein structure without needing homology information.
The method is based on the special side chain orientation of catalytic residues.
We found that the side chain of catalytic residues usually points to the center of the catalytic site.
The special orientation is usually observed in catalytic residues but not in noncatalytic residues, which usually have random side chain orientation.
The method is shown to be the most accurate catalytic residue prediction method currently when combined with PSI-Blast sequence conservation.
It performs better than other competing methods on several benchmark datasets that include over 1,200 enzyme structures.
The areas under the ROC curve (AUC) on these benchmark datasets are in the range from 0.934 to 0.968.
American Psychological Association (APA)
Lu, Chih-Hao& Yu, Chin-Sheng& Chien, Yu-Tung& Huang, Shao-Wei. 2014. EXIA2: Web Server of Accurate and Rapid Protein Catalytic Residue Prediction. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034571
Modern Language Association (MLA)
Lu, Chih-Hao…[et al.]. EXIA2: Web Server of Accurate and Rapid Protein Catalytic Residue Prediction. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1034571
American Medical Association (AMA)
Lu, Chih-Hao& Yu, Chin-Sheng& Chien, Yu-Tung& Huang, Shao-Wei. EXIA2: Web Server of Accurate and Rapid Protein Catalytic Residue Prediction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034571