The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model
Joint Authors
Bogacz, Anna
Mrozikiewicz, Przemyslaw M.
Karasiewicz, Monika
Bartkowiak-Wieczorek, Joanna
Mikolajczak, Przemyslaw L.
Ozarowski, Marcin
Grzeskowiak, Edmund
Majchrzycki, Marian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Valeriana officinalis is one of the most popular medicinal plants commonly used as a sedative and sleep aid.
It is suggested that its pharmacologically active compounds derived from the root may modulate the CYP3A4 gene expression by activation of pregnane X receptor (PXR) or constitutive androstane receptor (CAR) and lead to pharmacokinetic herb-drug interactions.
The aim of the study was to determine the influence of valerian on the expression level of CYP3A1 (homologue to human CYP3A4) as well as nuclear receptors PXR, CAR, RXR, GR, and HNF-4 α .
Male Wistar rats were given standardized valerian extract (300 mg/kg/day, p.o.) for 3 and 10 days.
The expression in liver tissue was analyzed by using real-time PCR.
Our result showed a decrease of CYP3A1 expression level by 35% ( P = 0.248 ) and 37% ( P < 0.001 ), respectively.
Moreover, Valeriana exhibited statistically significant reduction in RXR (approximately 28%) only after 3-day treatment.
We also demonstrated a decrease in the amount HNF-4 α by 22% ( P = 0.005 ) and 32% ( P = 0.012 ), respectively.
In case of CAR, the increase of expression level by 46% ( P = 0.023 ) was noted.
These findings suggest that Valeriana officinalis extract can decrease the CYP3A4 expression and therefore may lead to interactions with synthetic drugs metabolized by this enzyme.
American Psychological Association (APA)
Bogacz, Anna& Mrozikiewicz, Przemyslaw M.& Karasiewicz, Monika& Bartkowiak-Wieczorek, Joanna& Majchrzycki, Marian& Mikolajczak, Przemyslaw L.…[et al.]. 2014. The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034576
Modern Language Association (MLA)
Bogacz, Anna…[et al.]. The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034576
American Medical Association (AMA)
Bogacz, Anna& Mrozikiewicz, Przemyslaw M.& Karasiewicz, Monika& Bartkowiak-Wieczorek, Joanna& Majchrzycki, Marian& Mikolajczak, Przemyslaw L.…[et al.]. The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034576