Adenosine Amine Congener as a Cochlear Rescue Agent
Joint Authors
Thorne, Peter R.
Chang, Hao
Paek, Song Yee
Chi, Howard H.-T.
Sreebhavan, Sreevalsan
Telang, Ravindra S.
Tingle, Malcolm
Housley, Gary D.
Vlajkovic, Srdjan M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We have previously shown that adenosine amine congener (ADAC), a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury.
Here we demonstrate the dose-dependent rescue effects of ADAC on noise-induced cochlear injury in a rat model and establish the time window for treatment.
Methods.
ADAC (25–300 μg/kg) was administered intraperitoneally to Wistar rats (8–10 weeks old) at intervals (6–72 hours) after exposure to traumatic noise (8–16 kHz, 110 dB sound pressure level, 2 hours).
Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure.
Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration.
Results.
ADAC was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8–28 kHz).
Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products.
Conclusion.
Our data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment.
American Psychological Association (APA)
Vlajkovic, Srdjan M.& Chang, Hao& Paek, Song Yee& Chi, Howard H.-T.& Sreebhavan, Sreevalsan& Telang, Ravindra S.…[et al.]. 2014. Adenosine Amine Congener as a Cochlear Rescue Agent. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034582
Modern Language Association (MLA)
Vlajkovic, Srdjan M.…[et al.]. Adenosine Amine Congener as a Cochlear Rescue Agent. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1034582
American Medical Association (AMA)
Vlajkovic, Srdjan M.& Chang, Hao& Paek, Song Yee& Chi, Howard H.-T.& Sreebhavan, Sreevalsan& Telang, Ravindra S.…[et al.]. Adenosine Amine Congener as a Cochlear Rescue Agent. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1034582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034582