Autophagy: A Multifaceted Partner in Liver Fibrosis
Joint Authors
Codogno, Patrice
Mallat, Ariane
Lodder, Jasper
Teixeira-Clerc, Fatima
Moreau, Richard
Lotersztajn, Sophie
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Liver fibrosis is a common wound healing response to chronic liver injury of all causes, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide.
Fibrosis results from prolonged parenchymal cell apoptosis and necrosis associated with an inflammatory reaction that leads to recruitment of immune cells, activation and accumulation of fibrogenic cells, and extracellular matrix accumulation.
The fibrogenic process is driven by hepatic myofibroblasts, that mainly derive from hepatic stellate cells undergoing a transdifferentiation from a quiescent, lipid-rich into a fibrogenic myofibroblastic phenotype, in response to paracrine/autocrine signals produced by neighbouring inflammatory and parenchymal cells.
Autophagy is an important regulator of liver homeostasis under physiological and pathological conditions.
This review focuses on recent findings showing that autophagy is a novel, but complex, regulatory pathway in liver fibrosis, with profibrogenic effects relying on its direct contribution to the process of hepatic stellate cell activation, but with antifibrogenic properties via indirect hepatoprotective and anti-inflammatory properties.
Therefore, cell-specific delivery of drugs that exploit autophagic pathways is a prerequisite to further consider autophagy as a potential target for antifibrotic therapy.
American Psychological Association (APA)
Mallat, Ariane& Lodder, Jasper& Teixeira-Clerc, Fatima& Moreau, Richard& Codogno, Patrice& Lotersztajn, Sophie. 2014. Autophagy: A Multifaceted Partner in Liver Fibrosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034590
Modern Language Association (MLA)
Mallat, Ariane…[et al.]. Autophagy: A Multifaceted Partner in Liver Fibrosis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034590
American Medical Association (AMA)
Mallat, Ariane& Lodder, Jasper& Teixeira-Clerc, Fatima& Moreau, Richard& Codogno, Patrice& Lotersztajn, Sophie. Autophagy: A Multifaceted Partner in Liver Fibrosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034590