Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model
Joint Authors
Li, Jin-Feng
Han, Bing
Gong, Hui-Cui
Liu, Xin-Shan
Wang, Shan-Shan
Wang, Yu-Tong
Zhang, Yu-Zhen
Yin, Hong-Lei
Geng, Shuang
Wang, Yunliang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative movement disorder that is characterized by the progressive degeneration of the dopaminergic (DA) pathway.
Mesenchymal stem cells derived from human umbilical cord (hUC-MSCs) have great potential for developing a therapeutic agent as such.
HGF is a multifunctional mediator originally identified in hepatocytes and has recently been reported to possess various neuroprotective properties.
This study was designed to investigate the protective effect of hUC-MSCs infected by an adenovirus carrying the HGF gene on the PD cell model induced by MPP+ on human bone marrow neuroblastoma cells.
Our results provide evidence that the cultural supernatant from hUC-MSCs expressing HGF could promote regeneration of damaged PD cells at higher efficacy than the supernatant from hUC-MSCs alone.
And intracellular free Ca2+ obviously decreased after treatment with cultural supernatant from hUC-MSCs expressing HGF, while the expression of CaBP-D28k, an intracellular calcium binding protein, increased.
Therefore our study clearly demonstrated that cultural supernatant of MSC overexpressing HGF was capable of eliciting regeneration of damaged PD model cells.
This effect was probably achieved through the regulation of intracellular Ca2+ levels by modulating of CaBP-D28k expression.
American Psychological Association (APA)
Liu, Xin-Shan& Li, Jin-Feng& Wang, Shan-Shan& Wang, Yu-Tong& Zhang, Yu-Zhen& Yin, Hong-Lei…[et al.]. 2014. Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034602
Modern Language Association (MLA)
Liu, Xin-Shan…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034602
American Medical Association (AMA)
Liu, Xin-Shan& Li, Jin-Feng& Wang, Shan-Shan& Wang, Yu-Tong& Zhang, Yu-Zhen& Yin, Hong-Lei…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034602