Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies
Joint Authors
Chaiwongsa, Rujirek
Ongchai, Siriwan
Kunanusorn, Puongtip
Sangdee, Chaichan
Panthong, Ampai
Bunteang, Samreang
Nathasaen, Narong
Reutrakul, Vichai
Teekachunhatean, Supanimit
Hanprasertpong, Nutthiya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cryptolepis buchanani Roem.
& Schult.
is widely used in folk medicine in Southeast Asia for treating muscle tension and arthritis.
This study aimed to investigate an analgesic activity of the methanol extract of C.
buchanani (CBE) in acetic acid-induced writhing response in mice, and to examine its anti-inflammatory activity in ethyl phenylpropiolate- (EPP-) induced ear edema and carrageenan-induced paw edema in rats.
Its effects on cartilage degradation induced by interleukin-1β (IL-1β) in porcine cartilage explant culture were also determined.
This study demonstrated that CBE significantly reduced acetic acid-induced writhing response.
It also inhibited edema formation in both EPP-induced ear edema and carrageenan-induced paw edema models.
In cartilage explant culture, CBE significantly reduced the sulfated glycosaminoglycan and hyaluronan released into culture media while it reserved the uronic acid and collagen within the cartilage tissues.
It also suppressed the matrix metalloproteinase-2 activity with no effect on cell viability.
In conclusion, CBE shows analgesic, anti-inflammatory, and chondroprotective effects in this preliminary study.
Therefore, CBE may be useful as an alternative treatment for osteoarthritis.
American Psychological Association (APA)
Hanprasertpong, Nutthiya& Teekachunhatean, Supanimit& Chaiwongsa, Rujirek& Ongchai, Siriwan& Kunanusorn, Puongtip& Sangdee, Chaichan…[et al.]. 2014. Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034619
Modern Language Association (MLA)
Hanprasertpong, Nutthiya…[et al.]. Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034619
American Medical Association (AMA)
Hanprasertpong, Nutthiya& Teekachunhatean, Supanimit& Chaiwongsa, Rujirek& Ongchai, Siriwan& Kunanusorn, Puongtip& Sangdee, Chaichan…[et al.]. Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034619