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From Bench to Bedside: Immunotherapy for Prostate Cancer
Joint Authors
Power, Carl
Russell, Pamela J.
Nelson, Colleen C.
Jovanovic, Lidija
de Souza, Paul
Tse, Brian W. C.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The mainstay therapeutic strategy for metastatic castrate-resistant prostate cancer (CRPC) continues to be androgen deprivation therapy usually in combination with chemotherapy or androgen receptor targeting therapy in either sequence, or recently approved novel agents such as Radium 223.
However, immunotherapy has also emerged as an option for the treatment of this disease following the approval of sipuleucel-T by the FDA in 2010.
Immunotherapy is a rational approach for prostate cancer based on a body of evidence suggesting these cancers are inherently immunogenic and, most importantly, that immunological interventions can induce protective antitumour responses.
Various forms of immunotherapy are currently being explored clinically, with the most common being cancer vaccines (dendritic-cell, viral, and whole tumour cell-based) and immune checkpoint inhibition.
This review will discuss recent clinical developments of immune-based therapies for prostate cancer that have reached the phase III clinical trial stage.
A perspective of how immunotherapy could be best employed within current treatment regimes to achieve most clinical benefits is also provided.
American Psychological Association (APA)
Tse, Brian W. C.& Jovanovic, Lidija& Nelson, Colleen C.& de Souza, Paul& Power, Carl& Russell, Pamela J.. 2014. From Bench to Bedside: Immunotherapy for Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034621
Modern Language Association (MLA)
Tse, Brian W. C.…[et al.]. From Bench to Bedside: Immunotherapy for Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034621
American Medical Association (AMA)
Tse, Brian W. C.& Jovanovic, Lidija& Nelson, Colleen C.& de Souza, Paul& Power, Carl& Russell, Pamela J.. From Bench to Bedside: Immunotherapy for Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034621