Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation
Joint Authors
Beurskens, Charlotte J.
Brevoord, Daniel
Lagrand, Wim K.
van den Bergh, Walter M.
Preckel, Benedikt
Horn, Janneke
Juffermans, Nicole P.
Vroom, Margreeth B.
Source
Critical Care Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Helium is a noble gas with low density and increased carbon dioxide (CO2) diffusion capacity.
This allows lower driving pressures in mechanical ventilation and increased CO2 diffusion.
We hypothesized that heliox facilitates ventilation in patients during lung-protective mechanical ventilation using low tidal volumes.
Methods.
This is an observational cohort substudy of a single arm intervention study.
Twenty-four ICU patients were included, who were admitted after a cardiac arrest and mechanically ventilated for 3 hours with heliox (50% helium; 50% oxygen).
A fixed protective ventilation protocol (6 mL/kg) was used, with prospective observation for changes in lung mechanics and gas exchange.
Statistics was by Bonferroni post-hoc correction with statistical significance set at P < 0.017 .
Results.
During heliox ventilation, respiratory rate decreased ( 25 ± 4 versus 23 ± 5 breaths min−1, P = 0.010 ).
Minute volume ventilation showed a trend to decrease compared to baseline ( 11.1 ± 1.9 versus 9.9 ± 2.1 L min−1, P = 0.026 ), while reducing PaCO2 levels ( 5.0 ± 0.6 versus 4.5 ± 0.6 kPa, P = 0.011 ) and peak pressures ( 21.1 ± 3.3 versus 19.8 ± 3.2 cm H2O, P = 0.024 ).
Conclusions.
Heliox improved CO2 elimination while allowing reduced minute volume ventilation in adult patients during protective mechanical ventilation.
American Psychological Association (APA)
Beurskens, Charlotte J.& Brevoord, Daniel& Lagrand, Wim K.& van den Bergh, Walter M.& Vroom, Margreeth B.& Preckel, Benedikt…[et al.]. 2014. Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation. Critical Care Research and Practice،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034633
Modern Language Association (MLA)
Beurskens, Charlotte J.…[et al.]. Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation. Critical Care Research and Practice No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1034633
American Medical Association (AMA)
Beurskens, Charlotte J.& Brevoord, Daniel& Lagrand, Wim K.& van den Bergh, Walter M.& Vroom, Margreeth B.& Preckel, Benedikt…[et al.]. Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation. Critical Care Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034633