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Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors
Joint Authors
Qi, Yun-feng
Dong, Yan
Zheng, Li-hua
Bao, Yong-li
Sun, Lu-guo
Wu, Yin
Yu, Chun-lei
Jiang, Hong-yu
Huang, Yanxin
Li, Yuxin
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (HDAC) inhibitor approved by the US Food and Drug Administration (FDA).
SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes.
In particularly, SAHA induces selective apoptosis of tumor cells, although the mechanism is not well understood.
A series of microarray experiments was recently conducted to investigate tumor cell-selective proapoptotic transcriptional responses induced by SAHA.
Based on that gene expression time series, we propose a novel framework for detailed analysis of the mechanism of tumor cell apoptosis selectively induced by SAHA.
Our analyses indicated that SAHA selectively disrupted the DNA damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis.
Our results suggest a possible regulation network.
Our research extends the existing research.
American Psychological Association (APA)
Qi, Yun-feng& Huang, Yanxin& Dong, Yan& Zheng, Li-hua& Bao, Yong-li& Sun, Lu-guo…[et al.]. 2014. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034672
Modern Language Association (MLA)
Qi, Yun-feng…[et al.]. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1034672
American Medical Association (AMA)
Qi, Yun-feng& Huang, Yanxin& Dong, Yan& Zheng, Li-hua& Bao, Yong-li& Sun, Lu-guo…[et al.]. Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034672