Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin

Abstract EN

Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy.

This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG.

The patient reported having extracted his maxillary anterior teeth himself due to high mobility.

Clinical examination and radiographic images show a generalized and severe periodontitis.

No significant alterations in genetic or microbiological features were observed.

The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy.

Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts.

In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation.