Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions
Joint Authors
Kudo, Naoko
Kubo, Kagekatsu
Imashuku, Shinsaku
Oshima, Koichi
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Natural killer (NK) cells were proposed to play an important role in the pathogenesis of human T-cell lymphotropic virus type 1- (HTLV-1-) associated neurologic disease.
Our patient was a 77-year-old Japanese man, who had been treated for infective dermatitis associated with HTLV-1 for nearly 10 years.
When referred to us, he had facial eczema/edema as well as extensive dermatitis at the neck/upper chest and nuchal area/upper back regions.
Dermal lesions had CD3+CD4+ cells, but no NK cells.
Flow cytometry of his peripheral blood showed a phenotype of CD2+ (97%), CD3+ (17%), CD4+ (12%), CD7+ (94%), CD8+ (6%), CD11c+ (70%), CD16+ (82%), CD19+ (0%), CD20+ (0%), CD56+ (67%), HLA-DR+ (68%), and NKp46+ (36%).
Absolute numbers of CD56+NK cells in the peripheral blood were in a range of 986/μL–1,270/μL.
The expanded NK cells in the peripheral blood are considered to be reactive, to maintain the confinement of the HTLV-1-positive CD4+ cells in the skin, and to prevent the progression of the disease.
American Psychological Association (APA)
Imashuku, Shinsaku& Kudo, Naoko& Kubo, Kagekatsu& Oshima, Koichi. 2014. Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions. Case Reports in Dermatological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034707
Modern Language Association (MLA)
Imashuku, Shinsaku…[et al.]. Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions. Case Reports in Dermatological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034707
American Medical Association (AMA)
Imashuku, Shinsaku& Kudo, Naoko& Kubo, Kagekatsu& Oshima, Koichi. Expansion of Natural Killer Cells in Peripheral Blood in a Japanese Elderly with Human T-Cell Lymphotropic Virus Type 1-Related Skin Lesions. Case Reports in Dermatological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034707