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A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13)
Joint Authors
Li, Shibo
Gehrs, Bradley
Holter Chakrabarty, Jennifer
Cherry, Mohamad
Khawandanah, Mohamad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML).
Methods.
PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases.
Case.
A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia) with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD) mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected.
She was induced with 7 + 3 (cytarabine + idarubicin) and achieved complete remission after a second induction with high-dose cytarabine (HiDAC) followed by uneventful consolidation.
She presented 19 months after diagnosis with relapsed disease.
Of note, at relapse cytogenetic analysis revealed t (14; 15) (q32; q13), while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected).
She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used.
She continued to have persistent disease, and she was discharged on best supportive care.
Conclusion.
Based on this single case of AML with t (14; 15) (q32; q13), this newly reported translocation may be associated with refractory disease.
American Psychological Association (APA)
Khawandanah, Mohamad& Gehrs, Bradley& Li, Shibo& Holter Chakrabarty, Jennifer& Cherry, Mohamad. 2014. A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13). Case Reports in Genetics،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034727
Modern Language Association (MLA)
Khawandanah, Mohamad…[et al.]. A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13). Case Reports in Genetics No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034727
American Medical Association (AMA)
Khawandanah, Mohamad& Gehrs, Bradley& Li, Shibo& Holter Chakrabarty, Jennifer& Cherry, Mohamad. A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13). Case Reports in Genetics. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034727