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A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature
Joint Authors
Yun, Seongseok
Taverna, Josephine
Nair, Anju
Paulson, Spencer
Schatz, Jonathan H.
Persky, Daniel
Fuchs, Deborah
Puvvada, Soham
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A 65-year-old gentleman presented with left groin swelling over the course of two months.
Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions.
An excisional lymph node biopsy was performed.
Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells.
These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS).
FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown.
This case illustrates the diagnostic and therapeutic challenges of composite lymphomas.
This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.
American Psychological Association (APA)
Taverna, Josephine& Nair, Anju& Yun, Seongseok& Paulson, Spencer& Schatz, Jonathan H.& Persky, Daniel…[et al.]. 2014. A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034740
Modern Language Association (MLA)
Taverna, Josephine…[et al.]. A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature. Case Reports in Hematology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034740
American Medical Association (AMA)
Taverna, Josephine& Nair, Anju& Yun, Seongseok& Paulson, Spencer& Schatz, Jonathan H.& Persky, Daniel…[et al.]. A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034740