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Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia
Joint Authors
Modi, Anar
Alagusundaramoorthy, Sayee Sundar
Ghali, Wael
Agrawal, Abhinav
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 20 year old male was initially diagnosed suffering from Primary ciliary dyskinesia with symptoms of bronchiectasis, severe frontal, maxillary and ethmoid sinus disease.
At the age of 20, the patient was also diagnosed with Myelodysplastic syndrome requiring Bone marrow transplant due to the advanced stage at time of presentation.
Primary ciliary dyskinesia and Myelodsyplastic syndrome are both rare clinical conditions found in the general population, especially in young adults.
This rare combination of disorders has never been reported in literature to the best of the author’s knowledge.
The presence of an advanced cancer and a genetic abnormality due to two deletions occurring in two arms of the same chromosome can be explained on the base of chromothripsis.
A number of evidences have been published in the literature, about multiple deletions in chromosome 5 and advanced stages of MDS being associated with chromothripsis however this is the first case report on two deletions in chromosome 7 giving rise to two different clinical entities requiring multiple modes of management.
American Psychological Association (APA)
Agrawal, Abhinav& Modi, Anar& Alagusundaramoorthy, Sayee Sundar& Ghali, Wael. 2014. Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034741
Modern Language Association (MLA)
Agrawal, Abhinav…[et al.]. Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia. Case Reports in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1034741
American Medical Association (AMA)
Agrawal, Abhinav& Modi, Anar& Alagusundaramoorthy, Sayee Sundar& Ghali, Wael. Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034741