PML-IRIS during Fingolimod Diagnosed after Natalizumab Discontinuation
Joint Authors
Killestein, Joep
Vennegoor, A.
van Golde, A. E. L.
Bourez, R. L. J. H.
Wijlens, M. L. B.
Wattjes, M. P.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Natalizumab treatment is frequently discontinued and replaced by alternative medication in multiple sclerosis (MS) patients having a high risk of progressive multifocal leukoencephalopathy (PML).
Case Presentation.
We report a PML case that was missed on magnetic resonance imaging (MRI) at the time Natalizumab treatment was discontinued.
The patient subsequently developed a PML-immune reconstitution inflammatory syndrome after the initiation of Fingolimod treatment, suggesting that immune reconstitution may occur even during Fingolimod induced lymphopenia.
Conclusion.
This report highlights the need for strict drug surveillance using MRI of Natalizumab-associated MS patients at the time of drug discontinuation and beyond.
This is important with respect to pharmacovigilance purposes not only for Natalizumab, but also for alternative drugs used after Natalizumab discontinuation.
American Psychological Association (APA)
Killestein, Joep& Vennegoor, A.& van Golde, A. E. L.& Bourez, R. L. J. H.& Wijlens, M. L. B.& Wattjes, M. P.. 2014. PML-IRIS during Fingolimod Diagnosed after Natalizumab Discontinuation. Case Reports in Neurological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034818
Modern Language Association (MLA)
Killestein, Joep…[et al.]. PML-IRIS during Fingolimod Diagnosed after Natalizumab Discontinuation. Case Reports in Neurological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1034818
American Medical Association (AMA)
Killestein, Joep& Vennegoor, A.& van Golde, A. E. L.& Bourez, R. L. J. H.& Wijlens, M. L. B.& Wattjes, M. P.. PML-IRIS during Fingolimod Diagnosed after Natalizumab Discontinuation. Case Reports in Neurological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1034818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034818