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Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature
Joint Authors
Tanaka, Toshihide
Murayama, Y.
Sato, Kunitomo
Ishii, Takuya
Terao, Toru
Kato, Naoki
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gastrointestinal stromal tumor (GIST) is defined as a c-kit-positive gastrointestinal, mesenteric, or omental mesenchymal tumor that very rarely metastasizes to the brain.
Metastasis to the cerebellum is particularly rare.
An 80-year-old man presented with nausea and vomiting with disturbance of consciousness.
Magnetic resonance imaging (MRI) revealed tumor in the cerebellar vermis causing obstructive hydrocephalus.
The patient subsequently underwent midline suboccipital craniotomy, and the tumor was totally removed.
Immunohistochemical analysis showed tumor cells positive for c-kit and CD34, and cerebellar metastasis of GIST was diagnosed.
Postoperative radiotherapy was administered.
Following surgery and radiotherapy, the patient developed ileus caused by tumor in the small intestine and underwent laparotomy for tumor removal.
Following abdominal surgery, left hemiparesis and consciousness disturbance were noted.
Computed tomography showed recurrent large tumor with perifocal edema in the right frontal lobe of the brain.
The patient died 3 months after initial craniotomy.
Intracranial metastasis of GIST is extremely rare.
In cases such as the present, where the condition of the patient rapidly deteriorates and features such as rising intracranial pressure and ileus prevent the use of oral agents, molecular-targeted agents administered by intravenous infusion should be utilized.
American Psychological Association (APA)
Sato, Kunitomo& Tanaka, Toshihide& Kato, Naoki& Ishii, Takuya& Terao, Toru& Murayama, Y.. 2014. Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034852
Modern Language Association (MLA)
Sato, Kunitomo…[et al.]. Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1034852
American Medical Association (AMA)
Sato, Kunitomo& Tanaka, Toshihide& Kato, Naoki& Ishii, Takuya& Terao, Toru& Murayama, Y.. Metastatic Cerebellar Gastrointestinal Stromal Tumor with Obstructive Hydrocephalus Arising from the Small Intestine: A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034852