Pathological Complete Response and Long-Term Survival in a Very Elderly Patient after Neoadjuvant Chemotherapy for Locally Advanced, Unresectable Gastric Cancer
Joint Authors
Kobayashi, Mitsuyoshi
Sano, Takanori
Ebara, Kazuo
Mori, Hirohito
Izuishi, Kunihiko
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We address the pathological complete response and long-term survival of elderly patients after neoadjuvant chemotherapy in locally advanced, unresectable gastric cancer.
An 83-year-old man was hospitalized for upper abdominal pain.
Gastrointestinal endoscopy showed a large tumor spanning from the gastric angle to the antrum, and extending to the duodenum.
Histological analysis of the biopsy specimen revealed a poorly differentiated adenocarcinoma.
Computed tomography images showed thickening of the gastric wall and invasion of the body and head of the pancreas, but did not show distant metastases.
The patient was diagnosed with unresectable gastric cancer, and was treated with neoadjuvant chemotherapy using S-1 (80 mg/m2) and paclitaxel (60 mg/m2).
After the third course of chemotherapy, gastrointestinal endoscopy and abdominal computed tomography revealed a remarkable reduction in tumor size.
This reduction allowed distal gastrectomy to be conducted.
Histological examination of the specimen revealed no cancer cells in the primary lesion or lymph nodes.
The patient was treated with adjuvant chemotherapy of oral tegafur-uracil (300 mg/day) for one year after surgery.
He lived for five years after surgery without recurrence.
Neoadjuvant chemotherapy using S-1 and paclitaxel is a potent strategy for improving survival in very elderly patients with unresectable gastric cancer.
American Psychological Association (APA)
Izuishi, Kunihiko& Kobayashi, Mitsuyoshi& Sano, Takanori& Mori, Hirohito& Ebara, Kazuo. 2014. Pathological Complete Response and Long-Term Survival in a Very Elderly Patient after Neoadjuvant Chemotherapy for Locally Advanced, Unresectable Gastric Cancer. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034857
Modern Language Association (MLA)
Izuishi, Kunihiko…[et al.]. Pathological Complete Response and Long-Term Survival in a Very Elderly Patient after Neoadjuvant Chemotherapy for Locally Advanced, Unresectable Gastric Cancer. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1034857
American Medical Association (AMA)
Izuishi, Kunihiko& Kobayashi, Mitsuyoshi& Sano, Takanori& Mori, Hirohito& Ebara, Kazuo. Pathological Complete Response and Long-Term Survival in a Very Elderly Patient after Neoadjuvant Chemotherapy for Locally Advanced, Unresectable Gastric Cancer. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1034857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034857