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Metastatic Malignant Ectomesenchymoma Initially Presenting as a Pelvic Mass: Report of a Case and Review of Literature
Joint Authors
Wu, William W.
Romansky, S. G.
Nael, K.
Nael, A.
Shane, Lisa
Siaghani, P. J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pediatric soft tissue sarcomas account for approximately 10% of all pediatric malignancies.
Malignant ectomesenchymoma is rare biphasic sarcomas consisting of both mesenchymal and neuroectodermal elements.
Approximately 64 cases have been reported in the literature and are believed to arise from pluripotent embryologic migratory neural crest cells.
We report a 4-year-old boy who initially presented with a pelvic mass and inguinal lymphadenopathy at 6 months of age.
Inguinal lymph node biopsy revealed a distinct biphasic tumor with microscopic and immunophenotypic characteristics diagnostic for both alveolar rhabdomyosarcoma and poorly differentiated neuroblastoma.
The patient received national protocol chemotherapy against rhabdomyosarcoma with good response and presented with a cerebellar mass 21 months later.
The metastatic tumor revealed sheets of primitive tumor cells and diagnostic areas of rhabdomyosarcoma and neuroblastoma were identified only by immunohistochemistry.
Cytogenetic analysis of metastatic tumor demonstrated complex karyotype with multiple chromosomal deletions and duplications.
The patient received national protocol chemotherapy against neuroblastoma and adjuvant radiotherapy after surgical resection of the cerebellar tumor with good response.
He is currently off from any treatment for 18 months with no evidence of tumor recurrence or metastasis.
American Psychological Association (APA)
Nael, A.& Siaghani, P. J.& Wu, William W.& Nael, K.& Shane, Lisa& Romansky, S. G.. 2014. Metastatic Malignant Ectomesenchymoma Initially Presenting as a Pelvic Mass: Report of a Case and Review of Literature. Case Reports in Pediatrics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034925
Modern Language Association (MLA)
Nael, A.…[et al.]. Metastatic Malignant Ectomesenchymoma Initially Presenting as a Pelvic Mass: Report of a Case and Review of Literature. Case Reports in Pediatrics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034925
American Medical Association (AMA)
Nael, A.& Siaghani, P. J.& Wu, William W.& Nael, K.& Shane, Lisa& Romansky, S. G.. Metastatic Malignant Ectomesenchymoma Initially Presenting as a Pelvic Mass: Report of a Case and Review of Literature. Case Reports in Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034925