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Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals
Joint Authors
Sanchez-Corona, Jose
Ríos-González, Blanca Estela
Ibarra-Cortés, Bertha
Ramírez-López, Guadalupe
Magaña-Torres, María Teresa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP).
We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5 rs3135506, APOB rs1042031, FABP2 rs1799883, LDLR rs5925, LIPC rs1800588, LPL rs328, and MTTP rs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients.
A total of 160 HT patients and 160 normotensive individuals were included.
Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing.
The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic.
The alleles FABP2 p.55T, LIPC −514T, and MTTP −493T were associated with elevated systolic BP.
Five alleles were associated with lipids.
LPL p.474X and FABP2 p.55T were associated with decreased total cholesterol and LDL-C, respectively; APOA5 p.19W with increased HDL-C; APOA5 p.19W and FABP2 p.55T with increased triglycerides; and APOB p.4181K and LDLR c.1959T with decreased triglycerides.
The APOB p.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17–2.93; P=0.001) under the dominant model.
These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.
American Psychological Association (APA)
Ríos-González, Blanca Estela& Ibarra-Cortés, Bertha& Ramírez-López, Guadalupe& Sanchez-Corona, Jose& Magaña-Torres, María Teresa. 2014. Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035046
Modern Language Association (MLA)
Ríos-González, Blanca Estela…[et al.]. Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035046
American Medical Association (AMA)
Ríos-González, Blanca Estela& Ibarra-Cortés, Bertha& Ramírez-López, Guadalupe& Sanchez-Corona, Jose& Magaña-Torres, María Teresa. Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035046