Importance of Follow-Up Cerebrospinal Fluid Analysis in Cryptococcal Meningoencephalitis
Joint Authors
Trebst, Corinna
Stangel, Martin
Wurster, Ulrich
Skripuletz, Thomas
Schwenkenbecher, Philipp
Pars, Kaweh
Conzen, Josef
Bolat, Seza
Pul, Refik
Vonberg, Ralf-Peter
Sedlacek, Ludwig
Stoll, M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cryptococcal meningoencephalitis represents a serious infection of the central nervous system, where reliable prognostic factors during the disease course are needed.
Twenty-one patients diagnosed with cryptococcal meningoencephalitis in a German university hospital from 1999 to 2013 were analysed retrospectively.
CSF parameters were analysed prior to therapy and during antifungal treatment and were compared between patients who survived or deceased.
Fifteen patients clinically improved after antifungal therapy, while six patients died.
No differences were observed between the outcome groups for the CSF parameters cell count, lactate, total protein, and CSF-serum albumin quotients (QAlb).
Follow-up examinations of serum cryptococcal antigen titer and CSF cell count have shown that these parameters cannot be used to monitor the efficacy of antifungal therapy as well.
In contrast, the course of QAlb during therapy was indicative for the outcome as a possible prognostic marker.
In patients with clinical improvement QAlb values were falling under therapy, while rising QAlb values were found in patients with fatal outcome indicating a continuing dysfunction of the blood-CSF barrier.
In conclusion, our results indicate that, among the various CSF parameters, the course of QAlb presents a promising marker that might be used to monitor the efficacy of antifungal therapy.
American Psychological Association (APA)
Skripuletz, Thomas& Schwenkenbecher, Philipp& Pars, Kaweh& Stoll, M.& Conzen, Josef& Bolat, Seza…[et al.]. 2014. Importance of Follow-Up Cerebrospinal Fluid Analysis in Cryptococcal Meningoencephalitis. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035048
Modern Language Association (MLA)
Skripuletz, Thomas…[et al.]. Importance of Follow-Up Cerebrospinal Fluid Analysis in Cryptococcal Meningoencephalitis. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035048
American Medical Association (AMA)
Skripuletz, Thomas& Schwenkenbecher, Philipp& Pars, Kaweh& Stoll, M.& Conzen, Josef& Bolat, Seza…[et al.]. Importance of Follow-Up Cerebrospinal Fluid Analysis in Cryptococcal Meningoencephalitis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035048