Functional Polymorphisms of Matrix Metalloproteinases 1 and 9 Genes in Women with Spontaneous Preterm Birth
Joint Authors
Kapović, Miljenko
Peterlin, Borut
Pereza, Nina
Pleša, Ivana
Peterlin, Ana
Jan, Žiga
Tul, Nataša
Ostojić, Saša
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the association of functional MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB.
Methods and Patients.
A case-control study was conducted in 113 women with SPTB and 119 women with term delivery (control group).
Genotyping of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods.
Results.
There were no statistically significant differences in the distribution of neither individual nor combinations of genotype and allele frequencies of MMP-1-1607 1G/2G and MMP-9-1562 C/T polymorphisms between women with SPTB and control women.
Additionally, these polymorphisms do not contribute to any of the clinical characteristics of women with SPTB, including positive and negative family history of SPTB, gestational age at delivery, and maternal age at delivery, nor fetal birth weight.
Conclusion.
We did not find the evidence to support the association of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with SPTB in European Caucasian women.
American Psychological Association (APA)
Pereza, Nina& Pleša, Ivana& Peterlin, Ana& Jan, Žiga& Tul, Nataša& Kapović, Miljenko…[et al.]. 2014. Functional Polymorphisms of Matrix Metalloproteinases 1 and 9 Genes in Women with Spontaneous Preterm Birth. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035049
Modern Language Association (MLA)
Pereza, Nina…[et al.]. Functional Polymorphisms of Matrix Metalloproteinases 1 and 9 Genes in Women with Spontaneous Preterm Birth. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035049
American Medical Association (AMA)
Pereza, Nina& Pleša, Ivana& Peterlin, Ana& Jan, Žiga& Tul, Nataša& Kapović, Miljenko…[et al.]. Functional Polymorphisms of Matrix Metalloproteinases 1 and 9 Genes in Women with Spontaneous Preterm Birth. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035049