Transporter TAP1-637G and Immunoproteasome PSMB9-60H Variants Influence the Risk of Developing Vitiligo in the Saudi Population
Joint Authors
Elhawary, Nasser Attia
Tayeb, Mohammed Taher
Bogari, Neda
Jiffri, Essam Hussien
Rashad, Mona
Fatani, Abdulhamid
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We evaluated whether TAP1-rs1135216 (p.637D>G) and PSMB9-rs17587 (p.60R>H) were significantly associated with the risk and severity of vitiligo among Saudi patients.
One hundred seventy-two subjects were genotyped for the TAP1-rs1135216 and PSMB9-rs17587 variants using endonuclease digestions of amplified genomic DNA.
The TAP1-rs1135216 and PSMB9-rs17587 mutant alleles were strongly associated with vitiligo, with odds ratios showing five fold and two fold risks ( P < 0.0001 and P = 0.007 , resp.).
In TAP1-rs1135216, the 637G mutant allele was more frequent in cases (74%) than in healthy controls.
In cases, the 60H mutant allele PSMB9-rs17587 was less frequent (42%) than the wild-type 60R allele (58%).
Vitiligo vulgaris was the most common type of disease, associated with the DG (55%) and GG (46%) genotypes for rs1135216 and with the RH genotype (59%) for rs17587.
The heterozygous 637DG and 60RH genotypes were each linked with active phenotypes in 64% of cases.
In conclusion, the TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis.
Vitiligo vulgaris is associated with genotypes containing the mutant G and H alleles.
American Psychological Association (APA)
Elhawary, Nasser Attia& Bogari, Neda& Jiffri, Essam Hussien& Rashad, Mona& Fatani, Abdulhamid& Tayeb, Mohammed Taher. 2014. Transporter TAP1-637G and Immunoproteasome PSMB9-60H Variants Influence the Risk of Developing Vitiligo in the Saudi Population. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035052
Modern Language Association (MLA)
Elhawary, Nasser Attia…[et al.]. Transporter TAP1-637G and Immunoproteasome PSMB9-60H Variants Influence the Risk of Developing Vitiligo in the Saudi Population. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035052
American Medical Association (AMA)
Elhawary, Nasser Attia& Bogari, Neda& Jiffri, Essam Hussien& Rashad, Mona& Fatani, Abdulhamid& Tayeb, Mohammed Taher. Transporter TAP1-637G and Immunoproteasome PSMB9-60H Variants Influence the Risk of Developing Vitiligo in the Saudi Population. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035052