Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C
Joint Authors
Hu, Tsung-Hui
Chen, Chien-Hung
Kuo, Ming-Te
Wang, Jing-Houng
Lee, Chuan-Mo
Chiu, Yi-Chun
Hung, Chao-Hung
Lu, Sheng-Nan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed to determine whether neutrophil-to-lymphocyte ratio (NLR) could be a predictor of antiviral response in chronic hepatitis C patients.
A total of 602 consecutive patients (genotype 1, n = 263 ; genotype 2, n = 297 ; others/unknown, n = 42 ) receiving response-guided therapy with peginterferon plus ribavirin were recruited.
NLR was related to clinical and virological features and to treatment outcome.
Rapid virological response (RVR) and sustained virological response (SVR) were achieved in 436 (73%) and 458 (76%) of the patients, respectively.
Higher NLR (≥1.42) was found to be associated with higher prevalence of DM ( P = 0.039 ) and higher hepatitis C viral load ( P = 0.002 ) and white cell count ( P < 0.001 ).
NLR was significantly lower in patients with RVR and SVR compared to those without ( P = 0.032 and 0.034, resp.).
However, NLR was not an independent factor by multivariate analysis.
In the subgroup analysis, higher NLR (≥1.42) (odds ratio, 0.494, P = 0.038 ) was an independent poor predictor of SVR in genotype 2 patients but was not in genotype 1 patients.
In conclusion, NLR is a simple and easily accessible marker to predict response to peginterferon plus ribavirin therapy for chronic hepatitis C genotype 2.
American Psychological Association (APA)
Kuo, Ming-Te& Hu, Tsung-Hui& Lu, Sheng-Nan& Hung, Chao-Hung& Wang, Jing-Houng& Chen, Chien-Hung…[et al.]. 2014. Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035055
Modern Language Association (MLA)
Kuo, Ming-Te…[et al.]. Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035055
American Medical Association (AMA)
Kuo, Ming-Te& Hu, Tsung-Hui& Lu, Sheng-Nan& Hung, Chao-Hung& Wang, Jing-Houng& Chen, Chien-Hung…[et al.]. Neutrophil-to-Lymphocyte Ratio as a Predictor of Response to Peginterferon plus Ribavirin Therapy for Chronic Hepatitis C. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035055