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Elevated Plasma Stromal-Cell-Derived Factor-1 Protein Levels Correlate with Severity in Patients with Community-Acquired Pneumonia
Joint Authors
Yeh, Chao-Bin
Tsai, Ping-Kun
Wang, Hsiang-Ling
Chou, Ming-Chih
Yang, Shun-Fa
Hsieh, Ming-Ju
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The aim of this study was to investigate differential changes in plasma levels of stromal-cell-derived factor-1 (SDF-1) before and after antibiotic treatment in patients with community-acquired pneumonia (CAP) and observe the association between the severity of CAP and the plasma SDF-1 level.
Methods.
We gathered blood specimens from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls to measure the plasma concentrations of SDF-1 by using an enzyme-linked immunosorbent assay.
Results.
The plasma SDF-1 concentration was elevated significantly in patients with CAP before receiving treatment compared with the controls and decreased significantly after the patients received treatment.
Leukocyte (WBC) and neutrophil counts and C-reactive protein (CRP) levels decreased significantly after antibiotic treatment.
Moreover, differences in the plasma concentration of SDF-1 were significantly correlated with PSI, CURB-65, and APACHE II scores ( r = 0.389 , P = 0.002 , and n = 61 ; r = 0.449 , P < 0.001 , and n = 61 ; and r = 0.363 , P = 0.004 , and n = 61 , resp.).
Conclusions.
An elevated plasma SDF-1 concentration can be used as a biological marker for the early diagnosis of CAP and for the early detection of its severity.
American Psychological Association (APA)
Tsai, Ping-Kun& Hsieh, Ming-Ju& Wang, Hsiang-Ling& Chou, Ming-Chih& Yang, Shun-Fa& Yeh, Chao-Bin. 2014. Elevated Plasma Stromal-Cell-Derived Factor-1 Protein Levels Correlate with Severity in Patients with Community-Acquired Pneumonia. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035061
Modern Language Association (MLA)
Tsai, Ping-Kun…[et al.]. Elevated Plasma Stromal-Cell-Derived Factor-1 Protein Levels Correlate with Severity in Patients with Community-Acquired Pneumonia. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035061
American Medical Association (AMA)
Tsai, Ping-Kun& Hsieh, Ming-Ju& Wang, Hsiang-Ling& Chou, Ming-Chih& Yang, Shun-Fa& Yeh, Chao-Bin. Elevated Plasma Stromal-Cell-Derived Factor-1 Protein Levels Correlate with Severity in Patients with Community-Acquired Pneumonia. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035061