Peroxisome Proliferator-Activated Receptors Family Is Involved in the Response to Treatment and Mild Clinical Course in Patients with Ulcerative Colitis
Joint Authors
Jacintez-Cazares, M.
Fonseca-Camarillo, G.
Yamamoto-Furusho, Jesús K.
Furuzawa-Carballeda, Janette
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
PPARs play an important role in the regulation of intestinal inflammation.
Methods.
We included a total of 46 UC patients and 31 controls.
The gene expression of PPARs was measured by RT-PCR and protein expression by immunohistochemistry.
Results.
PPARα gene expression was significantly decreased in patients with active UC compared with remission UC group ( P = 0.001 ) and controls ( P = 0.001 ) .
We found that low gene expression of PPARα in mucosa confers a higher risk of UC activity ( P ≤ 0.0001 , OR = 22.6).
We observed an increase of PPARα expression in patients with UC who were treated with 5-aminosalicylates compared with those who received any other combined therapy ( P = 0.03 , OR = 0.08).
PPARγ gene expression was decreased in the active UC group compared with UC in remission ( P = 0.001 ) and control group ( P = 0.001 ) .
An increased expression of PPARγ gene was associated with mild clinical course of the disease ( P ≤ 0.001 , OR = 0.05).
No gene expression of PPARβ/δ was found in the colonic mucosa from UC patients and controls.
Conclusion.
Our results suggest that patients with high gene expression of PPARs have a better response to medical treatment and a mild clinical course of the disease.
American Psychological Association (APA)
Yamamoto-Furusho, Jesús K.& Jacintez-Cazares, M.& Furuzawa-Carballeda, Janette& Fonseca-Camarillo, G.. 2014. Peroxisome Proliferator-Activated Receptors Family Is Involved in the Response to Treatment and Mild Clinical Course in Patients with Ulcerative Colitis. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035068
Modern Language Association (MLA)
Yamamoto-Furusho, Jesús K.…[et al.]. Peroxisome Proliferator-Activated Receptors Family Is Involved in the Response to Treatment and Mild Clinical Course in Patients with Ulcerative Colitis. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035068
American Medical Association (AMA)
Yamamoto-Furusho, Jesús K.& Jacintez-Cazares, M.& Furuzawa-Carballeda, Janette& Fonseca-Camarillo, G.. Peroxisome Proliferator-Activated Receptors Family Is Involved in the Response to Treatment and Mild Clinical Course in Patients with Ulcerative Colitis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035068